Eyelid Papilloma – Know Its Causes, Symptoms, Treatments, Prognosis & More

Eyelid Papilloma - Causes, Symptoms, Treatments, Prognosis & More

Have you noticed any uncertain issue in your eyelid? Do you have an issue in your eyelid that something looks like skin tag? If yes then do not worry because it is an issue called eyelid papilloma which is one of the most common type of eyelid tumor. Well, in this blog, get to know what is eyelid papilloma and what can you do for eyelid papilloma removal. So, without wasting any time let’s just start knowing about eyelid papilloma here.


What Is Eyelid Papilloma?

Eyelid papilloma is an eyelid issue which is one of the most common types of eyelid tumors. This issue generally occurs in the middle age people who already have eyelid tumor. Eyelid papilloma is painless, benign and it further grows into cancer. This eyelid problem looks like a skin tag and it can be multiple or solitary, rough or smooth and it is quite similar in color to adjacent skin. There is a great need for eyelid papilloma removal when it becomes swollen or large.

Eyelid papilloma refers to nothing but a group of several benign epithelial proliferations having the possibility to affect the skin on the eyelid. These kinds of eyelid lesions are actually not related with the papillomavirus. Such benign or lesions are not so dangerous but it can cause little irritation or be not favorable cosmetically for the eyelid tumor patients.

Sometimes it becomes so vital so that it can able to differentiate benign eyelid lesions just like papillomas from possibly malignant lesions on the eyelids. The eyelid lesion are not actually limited to pseudoepitheliomatous hyperplasia, seborrheic keratosis, verruca vulgaris, basosquamous acanthoma, inverted follicular keratosis, squamous acanthoma and inverted follicular keratosis. There are several types of eyelid papilloma and they are described below:

#1: Seborrheic Keratosis

Seborrheic Keratosis is a benign cell’s proliferation. This has a ‘stuck on’ type appearance and it can have several degrees of eyelid pigmentation. These lesions tend to changes from a pink color or flesh to dark brown color. Such lesions are very well circumscribed and they are generally slightly elevated. Sometimes, these lesions can have an inflamed base and that is known as Leser-Trelat sign.

#2: Squamous Papilloma

Squamous papilloma is another type of eyelid papilloma and is also known as acrochordon or skin tag. This type of papilloma is a flesh-colored and soft lesions that are too smooth to touch and is round or pedunculated.

#3: Inverted Follicular Keratosis

Another type of eyelid papilloma is Inverted Follicular Keratosis. It is generally a solitary lesion that affects the eyelid margin. This kind of papilloma may be pigmented or it may not be pigmented and it has been described as nodular or papillary when it comes to the appearance.

#4: Pseudoepitheliomatous Hyperplasia

Pseudoepitheliomatous Hyperplasia is generally reactive processes in response to wound, trauma, pharmaceutical agents, burn, etc. and they can appear similar to a squamous cell or basal cell carcinoma. This type of lesions is generally evaluated on the eyelid skin with an irregular surface and is sometimes crusting or ulceration.

#5: Verruca Vulgaris

Last, but not the least, another type of eyelid papilloma is the verruca vulgaris. This type of lesion is a flesh-colored skin growth that is caused due to human papillomavirus. Verruca vulgaris is quite rare on the eyelid.

These are some types of eyelid papilloma and now in the next section, before we move on to look at the eyelid papilloma removal ways, you will get to know about the causes of eyelid papilloma.

What Causes Eyelid Papilloma?

What Causes Eyelid Papilloma

When it comes to the causes of the eyelid papilloma, one of the most common causes is the human papillomavirus. However, for some papilloma, only human papillomavirus (HPV) is not the main cause. Here, I can give you an example, inverted papilloma; it is generally caused due to smoking or other related causes.

Sometimes, skin damage can also promote the development of a papilloma. Picking or scratching a wart can sometimes also lead to further eye or eyelid infection. However, there is a link between cancer and HPV, most specifically cervical cancer. It has been observed by the researchers that it takes between 10 to 30 years for HPV to develop into a dangerous condition.

Now, in the next section, you will get to know the possible signs and symptoms which show that you have eyelid papilloma issue. So, go through the below section of the blog.


Symptoms Of Eyelid Papilloma

Generally, most of the eyelid papilloma does not produce any symptoms beyond eye area skin irritation. But they can cause worry and impact self-esteem in some people because of their appearance. Only a few eyelid papilloma produce some medical symptoms.

The lump under eyelid may not be so dangerous but it can push against nearby structures which also includes the eye area. So, removal of lump is so important so that it cannot further give birth to papilloma.

Now, you can learn how to diagnose eyelid papilloma before going through the eyelid papilloma removal process.

How To Diagnose Eyelid Papilloma?

How To Diagnose Eyelid Papilloma

Well, when it comes to diagnosing the eyelid papilloma, it usually involves getting an ultrasound or mammogram. Diagnosing an eyelid papilloma can be achieved through:

  • Ultrasound of the infected area
  • A mammogram

The images that are taken from the tests as mentioned above can determine the following:

Location: Some eyelid papilloma can be so hard to spot with the naked eye.

Size: The eyelid papilloma treatment may depend on the size of the eyelid papilloma.

Sometimes a biopsy may also be performed to examine the cells within the papilloma. This test rules out other conditions like ductal carcinoma and atypical ductal hyperplasia.

Now, in the next section, I am going to introduce with the best eyelid papilloma removal treatment. So, do not skip going through this and see how you can treat eyelid papilloma with ease.

Eyelid Papilloma Removal Treatment

Eyelid Papilloma Removal Treatment

Some lesions or benign that are generally found to be eyelid papilloma can be easily observed. If the eyelid papilloma causes irritation or is cosmetically unacceptable for the people suffering from eyelid tumor. Most of the eyelid papilloma removal can be done with a bedside shave excision.

Different types of eyelid papilloma have different removal treatment. As for example, verruca vulgaris actually responds better to to the removal process called cryotherapy. In a study, it has been found that to treat large eyelid papilloma, intralesional interferon is considered.

But, commonly papilloma excision removal technique is considered for eyelid papilloma removal treatment. So, let’s go through this technique in the below section of this blog:

Papilloma Excision Technique

Papilloma Excision Technique

When it comes to the eyelid papilloma removal treatment, the process involves the instill topical tetracaine to be dropped in the ipsilateral eye just to prevent the irritation of the eye from the cleaning solution. You can use the solution of full strength povidone-iodine so that you can clean the papilloma area and related surrounding the eyelid tissue. After this, you can place the small sterile drape with a hole must cut out so that it can isolate eyelid lesions.

You need to instill 1 mL to 2 mL of lidocaine along with epinephrine underneath the papilloma directly. After this, use the very less amount of local anesthesia important to provide limited or adequate patient comfort.

With the use of 0.5mm forceps, grasp tissue and then gently elevate while using iris scissor or 15 blade so that it can remove the eyelid lesions. Make sure that you start cutting at the lesion’s base to remove completely. There is no need to enter into deeper tissues. A handled cautery tool is used during the process to achieve hemostasis. However, typically the remaining defect is so small and does not need any suturing to approximate eyelid skin.

Some prescribed antibiotic for the related patients need to be placed on healing incision for 3 to 4 times every day for 2 to 3 weeks until the healed is over to prevent infection.

Some Other Eyelid Papilloma Removal Treatments

Apart from papilloma excision technique, doctors can also burn, freeze or cut away papilloma. Or doctors can also treat warts on the skin with the use of the following methods:

  • Excision – With this, the doctor surgically removes the papilloma.
  • Laser Surgery – This procedure destroys the wart with the use of hi9gh-energy light from a laser.
  • Cautery – It involves burning off the tissue and after that scraping it away with the use of curettage.
  • Cryotherapy – This is freezing off the tissue.

Eyelid Papilloma Prognosis

When the cells within the intraductal papilloma are found to be non-cancerous, the outlook is typically good after the growth is removed.

If cancerous or abnormal cells are found then the possible treatments may include the surgery and more frequent mammograms.


Eyelid papilloma is an eyelid issue that takes place when a person is suffering from eyelid tumor. From the above sections of this blog, you might have learned everything about eyelid papilloma and its related causes, symptoms, eyelid papilloma removal treatment.

You can try the eyelid papilloma removal treatment mentioned above which is very effective for those who already have eyelid tumor do not waste your time anymore and just get your issue treated with the treatments for eyelid papilloma mentioned in this blog.


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Eyelid Papilloma - Know Its Causes, Symptoms, Treatments, Prognosis & More
Learn everything about eyelid papilloma (eyelid tumor). Also know its removal treatments by lesion techniques, excision techniques and more.